The 24 teams from the group stage and the eight third in the Champions League group stage have formed 16 pairs.
The teams were divided into two: the winners of the groups and the runners-ups. According to the pre-imposed restriction, teams from one country could not meet each other, as well as teams in one subgroup at the group stage.
As a result of the draw, the eighth-final pairs were formed as follows:
Wolfsberger - Tottenham
Dynamo Kiev - Bruges
Real Sociedad - Manchester United
Benfica - Arsenal
Crvena Zvezda - Milan
Antwerp - Rangers
Slavia Praha - Leicester City
RB Salzburg - Villarreal
Braga - Roma
Krasnodar - Dinamo (Z)
Young Boys - Leverkusen
Molde - Hoffenheim
Granada - Naples
Maccabi Tel Aviv - Shakhtar Donetsk
Ajax - Lille
Olympiacos - Eindhoven
The first matches will be held on February 18, 2021, the repeat ones on February 25.